Treatments

These posts deal with some the possible treatments for prostate cancer.

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High-dose-rate brachytherapy boost for prostate cancer: rationale and technique

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High-dose-rate brachytherapy (HDR) is a method of conformal dose escalation to the prostate. It can be used as a local boost in combination with external beam radiotherapy, with a high degree of efficacy and low rate of long term toxicity. Data consistently reports relapse free survival rates of greater than 90% for intermediate risk patients and greater than 80% for high risk. Results are superior to those achieved with external beam radiotherapy alone. Read the article. (Free UroToday login required.)

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Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes

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Objectives. To assess the treatment outcomes of a single session of whole gland high intensity focused ultrasound (HIFU) for patients with localized prostate cancer (PCa). Methods. Response rates were defined using the Stuttgart and Phoenix criteria. Complications were graded according to the Clavien score. Results. At a median follow-up of 94months, 48 (44.4%) and 50 (46.3%) patients experienced biochemical recurrence for Phoenix and Stuttgart definition, respectively. The 5- and 10-year actuarial biochemical recurrence free survival rates were 57% and 40%, respectively. The 10-year overall survival rate, cancer specific survival rate, and metastasis free survival rate were 72%, 90%, and 70%,

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“Surveillance” May Be Safest for Low-Risk Prostate Cancer

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Among men whose low-risk prostate cancer was managed with so-called active surveillance for up to 15 years, just 1.5 percent died of the cancer, according to new data from a Canadian study. That result is similar to outcomes in men whose cancers are treated immediately, the authors write. Read the article from Scientific American.

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Advances in Prostate Cancer: 2014

PSA Screening, Active Surveillance, Advanced Prostate Cancer, Diagnosis, Diet, Supplements / By / / 1 minute of reading

The year 2014 has again provided important developments in the area of prostate cancer. New data and new treatments span the spectrum of prostate cancer management, from prevention and screening to optimal strategies for localized, locally advanced, and metastatic disease. Read the article.  (Free Medscape account required.)

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Low-Risk and Very-Low-Risk Prostate Cancer: Is There a Role for Focal Therapy in the Era of Active Surveillance? Yes, the Two Approaches Complement Each Other

Active Surveillance, Focal Therapy / By / / 1 minute of reading

The challenge in prostate cancer (PCa) is to match the aggressiveness of the treatment to that of the cancer. Until recently, all screen-diagnosed localized cancers were considered at least potentially aggressive and in most cases were treated radically. Active surveillance represented a major step forward in acknowledging that some cancers were clinically insignificant and did not pose a threat to the patient’s life. Recently, a third option—focal therapy—has emerged as a potential middle ground between radical treatment and active surveillance. Read the article.

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Managing bone health in patients with prostate cancer

Advanced Prostate Cancer, Exercise, Hormone Therapy, Supplements / By / / 1 minute of reading

Department of Surgery, University of Toronto, Humber River Hospital, Toronto, Ontario, Canada BARKIN J. How I Do It: Managing bone health in patients with prostate cancer. Can J Urol 2014;21(4): 7399-7403. Urologists have two scenarios where they have to address bone loss or increased risk of fractures in men with prostate cancer. In the first setting, a patient who has been started on androgen deprivation therapy may develop cancer-treatment-induced bone loss. In the second setting, a patient’s prostate cancer may have metastasized to the bone. This article describes six steps to manage bone health in patients diagnosed with prostate cancer

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Good Prostate Cancer Outcomes Possible Despite Salvage Radiation Failure

Radiation, Radical Prostatectomy / By / / 1 minute of reading

Salvage radiation therapy (SRT) given after radical prostatectomy may improve outcomes in prostate cancer (PCa) patients, even in those who fail the treatment, according to study findings presented at the 56th annual meeting of the American Society for Radiation Oncology in San Francisco. Read the article.

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Aspirin Eases Genitourinary Toxicity from Prostate Cancer Radiotherapy

Radiation, Supplements / By / / 1 minute of reading

Low-dose aspirin use is independently associated with decreased acute genitourinary (GU) toxicity in patients undergoing radiotherapy for prostate cancer (PCa), researchers reported at the American Society for Radiation Oncology 56th annual meeting in San Francisco. Read the article.

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Brachytherapy Offers Favorable Long-Term Prostate Cancer Survival

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Brachytherapy for prostate cancer (PCa) is associated with favorable 15-year cancer-specific survival, particularly in patients with high-risk disease, a study found. In addition, brachytherapy patients who receive hormone therapy for more than 6 months have decreased all-cause survival. Read the article.

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